Upper Mississippi River

Discover the beauty of the Upper Mississippi on this 8-night autumnal journey aboard American Cruise Lines’ American Serenade. Begin with a complimentary pre-cruise hotel stay in St. Paul, Minnesota, renowned for its dynamic arts scene and picturesque lakes. Embark in Red Wing, a city whose pioneering story lives on in its many galleries and museums, and set sail for La Crosse. Then head to Dubuque, where you can visit the Museum of Art, Iowa’s oldest cultural institution. Explore the many districts of downtown Dubuque including Cable Car Square, the Historic Millwork District, and Historic Old Main District, once a hideaway for notorious gangster Al Capone. Enjoy the serene landscape as head to Davenport before stopping in Hannibal, to visit the boyhood home of Mark Twain and famously known as the setting for many of his writings. Finally, complete your voyage near St. Louis, famous for its soaring arch.